{"id":89250,"date":"2024-07-22T16:14:45","date_gmt":"2024-07-22T16:14:45","guid":{"rendered":"https:\/\/www.stress.org\/?post_type=news&#038;p=89250"},"modified":"2024-07-08T18:04:14","modified_gmt":"2024-07-08T18:04:14","slug":"exaggerated-amygdala-response-to-masked-facial-stimuli-in-posttraumatic-stress-disorder-a-functional-mri-study","status":"publish","type":"news","link":"https:\/\/www.stress.org\/news\/exaggerated-amygdala-response-to-masked-facial-stimuli-in-posttraumatic-stress-disorder-a-functional-mri-study\/","title":{"rendered":"Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study"},"content":{"rendered":"<header id=\"heading\" class=\"heading\">\n<div id=\"full-view-heading\" class=\"full-view\">\n<div class=\"inline-authors\">\n<div class=\"authors\">\n<div class=\"authors-list\"><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Rauch+SL&amp;cauthor_id=10812035\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"S L Rauch\">S L Rauch<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, USA.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10812035\/#full-view-affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Whalen+PJ&amp;cauthor_id=10812035\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"P J Whalen\">P J Whalen<\/a><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Shin+LM&amp;cauthor_id=10812035\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"L M Shin\">L M Shin<\/a><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=McInerney+SC&amp;cauthor_id=10812035\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"S C McInerney\">S C McInerney<\/a><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Macklin+ML&amp;cauthor_id=10812035\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"M L Macklin\">M L Macklin<\/a><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Lasko+NB&amp;cauthor_id=10812035\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"N B Lasko\">N B Lasko<\/a><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Orr+SP&amp;cauthor_id=10812035\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"S P Orr\">S P Orr<\/a><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Pitman+RK&amp;cauthor_id=10812035\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"R K Pitman\">R K Pitman<\/a><\/span><\/div>\n<\/div>\n<\/div>\n<div class=\"short-article-details\">Affiliations\u00a0<button id=\"toggle-authors\" class=\"more-details active\" data-alt-text=\"Collapse\" aria-controls=\"expanded-authors\" aria-expanded=\"true\" data-pinger-ignore=\"\" data-fetch-url=\"\/10812035\/long-authors\/\" data-id-prefix=\"\"><span class=\"title\">collapse<\/span><\/button><\/div>\n<div id=\"expanded-authors\" class=\"extended-article-details\" aria-hidden=\"false\">\n<div id=\"full-view-expanded-authors\" class=\"expanded-authors\">\n<div class=\"affiliations\">\n<h3 class=\"title\">Affiliation<\/h3>\n<ul class=\"item-list\">\n<li id=\"full-view-affiliation-1\" data-affiliation-id=\"full-view-affiliation-1\"><sup class=\"key\">1<\/sup>Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, USA.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<ul id=\"full-view-identifiers\" class=\"identifiers\">\n<li><span class=\"identifier pubmed\"><span class=\"id-label\">PMID:\u00a0<\/span><strong class=\"current-id\" title=\"PubMed ID\">10812035<\/strong><\/span><\/li>\n<li><span class=\"identifier doi\"><span class=\"id-label\">DOI:\u00a0<\/span><a class=\"id-link\" href=\"https:\/\/doi.org\/10.1016\/s0006-3223(00)00828-3\" target=\"_blank\" rel=\"noopener\" data-ga-category=\"full_text\" data-ga-action=\"DOI\">10.1016\/s0006-3223(00)00828-3<\/a><\/span><\/li>\n<\/ul>\n<\/div>\n<\/header>\n<div id=\"abstract\" class=\"abstract\">\n<h2 class=\"title\">Abstract<\/h2>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p><strong class=\"sub-title\">Background:\u00a0<\/strong>Converging lines of evidence have implicated the amygdala in the pathophysiology of posttraumatic stress disorder (PTSD). We previously developed a method for measuring automatic amygdala responses to general threat-related stimuli; in conjunction with functional magnetic resonance imaging, we used a passive viewing task involving masked presentations of human facial stimuli.<\/p>\n<p><strong class=\"sub-title\">Methods:\u00a0<\/strong>We applied this method to study veterans with PTSD and a comparison cohort of combat-exposed veterans without PTSD.<\/p>\n<p><strong class=\"sub-title\">Results:\u00a0<\/strong>The findings indicate that patients with PTSD exhibit exaggerated amygdala responses to masked-fearful versus masked-happy faces.<\/p>\n<p><strong class=\"sub-title\">Conclusions:\u00a0<\/strong>Although some previous neuroimaging studies of PTSD have demonstrated amygdala recruitment in response to reminders of traumatic events, this represents the first evidence for exaggerated amygdala responses to general negative stimuli in PTSD. Furthermore, by using a probe that emphasizes automaticity, we provide initial evidence of amygdala hyperresponsivity dissociated from the &#8220;top-down&#8221; influences of medial frontal cortex.<\/p>\n<\/div>\n<\/div>\n<p><a href=\"https:\/\/www.pexels.com\/photo\/finger-pointing-to-a-brain-scan-4226119\/\">Photo by Anna Shvets<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10812035\/\">Post PubMed<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>S L Rauch\u00a01,\u00a0P J Whalen,\u00a0L M Shin,\u00a0S C McInerney,\u00a0M L Macklin,\u00a0N B Lasko,\u00a0S P Orr,\u00a0R K Pitman Affiliations\u00a0collapse Affiliation 1Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, [&hellip;]<\/p>\n","protected":false},"featured_media":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false,"give_campaign_id":0,"pmpro_default_level":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false},"categories":[12,241,139,142,15,182,731],"tags":[136,137,138,236,141,155,242],"class_list":["post-89250","news","type-news","status-publish","format-standard","hentry","category-adult-stress","category-combat-stress-and-ptsd-blog","category-daily-life-blog","category-health","category-mental-health","category-military-stress","category-ptsd","tag-ais","tag-american-institute-of-stress","tag-anxiety","tag-combat-stress","tag-health","tag-research","tag-wounded-warrior","pmpro-has-access"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study - The American Institute of Stress<\/title>\n<meta name=\"description\" content=\"posttraumatic stress disorder, amygdala in the pathophysiology of posttraumatic stress disorder (PTSD), PTSD exhibit exaggerated amygdala responses, negative stimuli in PTSD.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.stress.org\/news\/exaggerated-amygdala-response-to-masked-facial-stimuli-in-posttraumatic-stress-disorder-a-functional-mri-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study - The American Institute of Stress\" \/>\n<meta property=\"og:description\" content=\"posttraumatic stress disorder, amygdala in the pathophysiology of posttraumatic stress disorder (PTSD), PTSD exhibit exaggerated amygdala responses, negative stimuli in PTSD.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.stress.org\/news\/exaggerated-amygdala-response-to-masked-facial-stimuli-in-posttraumatic-stress-disorder-a-functional-mri-study\/\" \/>\n<meta property=\"og:site_name\" content=\"The American Institute of Stress\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.stress.org\/wp-content\/uploads\/2024\/07\/pexels-shvetsa-4226119-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1707\" \/>\n\t<meta property=\"og:image:height\" content=\"2560\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.stress.org\/news\/exaggerated-amygdala-response-to-masked-facial-stimuli-in-posttraumatic-stress-disorder-a-functional-mri-study\/\",\"url\":\"https:\/\/www.stress.org\/news\/exaggerated-amygdala-response-to-masked-facial-stimuli-in-posttraumatic-stress-disorder-a-functional-mri-study\/\",\"name\":\"Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study - The American Institute of Stress\",\"isPartOf\":{\"@id\":\"https:\/\/www.stress.org\/#website\"},\"datePublished\":\"2024-07-22T16:14:45+00:00\",\"description\":\"posttraumatic stress disorder, amygdala in the pathophysiology of posttraumatic stress disorder (PTSD), PTSD exhibit exaggerated amygdala responses, negative stimuli in PTSD.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.stress.org\/news\/exaggerated-amygdala-response-to-masked-facial-stimuli-in-posttraumatic-stress-disorder-a-functional-mri-study\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.stress.org\/news\/exaggerated-amygdala-response-to-masked-facial-stimuli-in-posttraumatic-stress-disorder-a-functional-mri-study\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.stress.org\/news\/exaggerated-amygdala-response-to-masked-facial-stimuli-in-posttraumatic-stress-disorder-a-functional-mri-study\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"News\",\"item\":\"https:\/\/www.stress.org\/news\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.stress.org\/#website\",\"url\":\"https:\/\/www.stress.org\/\",\"name\":\"The American Institute of Stress\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.stress.org\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.stress.org\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.stress.org\/#organization\",\"name\":\"The American Institute of Stress\",\"url\":\"https:\/\/www.stress.org\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.stress.org\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.stress.org\/wp-content\/uploads\/2023\/07\/AIS-logo-C.svg\",\"contentUrl\":\"https:\/\/www.stress.org\/wp-content\/uploads\/2023\/07\/AIS-logo-C.svg\",\"width\":1440,\"height\":432,\"caption\":\"The American Institute of Stress\"},\"image\":{\"@id\":\"https:\/\/www.stress.org\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study - The American Institute of Stress","description":"posttraumatic stress disorder, amygdala in the pathophysiology of posttraumatic stress disorder (PTSD), PTSD exhibit exaggerated amygdala responses, negative stimuli in PTSD.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.stress.org\/news\/exaggerated-amygdala-response-to-masked-facial-stimuli-in-posttraumatic-stress-disorder-a-functional-mri-study\/","og_locale":"en_US","og_type":"article","og_title":"Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study - The American Institute of Stress","og_description":"posttraumatic stress disorder, amygdala in the pathophysiology of posttraumatic stress disorder (PTSD), PTSD exhibit exaggerated amygdala responses, negative stimuli in PTSD.","og_url":"https:\/\/www.stress.org\/news\/exaggerated-amygdala-response-to-masked-facial-stimuli-in-posttraumatic-stress-disorder-a-functional-mri-study\/","og_site_name":"The American Institute of Stress","og_image":[{"width":1707,"height":2560,"url":"https:\/\/www.stress.org\/wp-content\/uploads\/2024\/07\/pexels-shvetsa-4226119-scaled.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.stress.org\/news\/exaggerated-amygdala-response-to-masked-facial-stimuli-in-posttraumatic-stress-disorder-a-functional-mri-study\/","url":"https:\/\/www.stress.org\/news\/exaggerated-amygdala-response-to-masked-facial-stimuli-in-posttraumatic-stress-disorder-a-functional-mri-study\/","name":"Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study - The American Institute of Stress","isPartOf":{"@id":"https:\/\/www.stress.org\/#website"},"datePublished":"2024-07-22T16:14:45+00:00","description":"posttraumatic stress disorder, amygdala in the pathophysiology of posttraumatic stress disorder (PTSD), PTSD exhibit exaggerated amygdala responses, negative stimuli in PTSD.","breadcrumb":{"@id":"https:\/\/www.stress.org\/news\/exaggerated-amygdala-response-to-masked-facial-stimuli-in-posttraumatic-stress-disorder-a-functional-mri-study\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.stress.org\/news\/exaggerated-amygdala-response-to-masked-facial-stimuli-in-posttraumatic-stress-disorder-a-functional-mri-study\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.stress.org\/news\/exaggerated-amygdala-response-to-masked-facial-stimuli-in-posttraumatic-stress-disorder-a-functional-mri-study\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"News","item":"https:\/\/www.stress.org\/news\/"},{"@type":"ListItem","position":2,"name":"Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study"}]},{"@type":"WebSite","@id":"https:\/\/www.stress.org\/#website","url":"https:\/\/www.stress.org\/","name":"The American Institute of Stress","description":"","publisher":{"@id":"https:\/\/www.stress.org\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.stress.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.stress.org\/#organization","name":"The American Institute of Stress","url":"https:\/\/www.stress.org\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.stress.org\/#\/schema\/logo\/image\/","url":"https:\/\/www.stress.org\/wp-content\/uploads\/2023\/07\/AIS-logo-C.svg","contentUrl":"https:\/\/www.stress.org\/wp-content\/uploads\/2023\/07\/AIS-logo-C.svg","width":1440,"height":432,"caption":"The American Institute of Stress"},"image":{"@id":"https:\/\/www.stress.org\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.stress.org\/wp-json\/wp\/v2\/news\/89250","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.stress.org\/wp-json\/wp\/v2\/news"}],"about":[{"href":"https:\/\/www.stress.org\/wp-json\/wp\/v2\/types\/news"}],"wp:attachment":[{"href":"https:\/\/www.stress.org\/wp-json\/wp\/v2\/media?parent=89250"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.stress.org\/wp-json\/wp\/v2\/categories?post=89250"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.stress.org\/wp-json\/wp\/v2\/tags?post=89250"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}